Sirtuins are types of proteins that directly impact the SIRT genes, cellular aging, and DNA expression that affect quality aging and longevity. Activation of the sirtuin proteins and SIRT genes are linked with lifespan, cell survival, insulin regulation and neuroprotection. Activation of sirtuins are central regulators of mitochondrial activity, membrane potential and metabolism in the brain essential for cellular and electrical energy in your brain. Sirtuins play important roles in aging well and neuroprotection.