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Fisetin, a potential caloric restriction mimetic, attenuates senescence biomarkers in rat erythrocytes.

An imbalanced redox status is a hallmark of the aging process. Caloric restriction mimetics (CRMs) are compounds that produce caloric...

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Fisetin as a caloric restriction mimetic protects rat brain against aging induced oxidative stress, apoptosis and neurodegeneration.

AIM:In the present study, attempts have been made to evaluate the potential role of fisetin, a caloric restriction mimetic (CRM),...

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Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves

Despite technological advances, the survival records from longevity experiments remain the most indispensable tool in ageing-related research. A variety of...

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Effects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementia.

This study was designed to investigate the effects of fisetin (FST) on hyperhomocysteinemia (HHcy)-induced experimental endothelial dysfunction (ED) and vascular...

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Fisetin impedes developmental methylmercury neurotoxicity via downregulating apoptotic signalling pathway and upregulating Rho GTPase signalling pathway in hippocampus of F1 generation rats.

Methyl mercury is a teratogenic and neurodevelopmental toxicant in the environment. MeHg affects several biological pathways critical for brain development....

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Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy.

A wide variety of chronic diseases, such as neurodegenerative and cardiovascular disorders, diabetes mellitus, osteoarthtitis, obesity and various cancers, are...

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Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse.

Alzheimer's disease (AD) is rarely addressed in the context of aging even though there is an overlap in pathology. We...

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How fisetin reduces the impact of age and disease on CNS function.

It is becoming increasingly clear that neurological diseases are multi-factorial involving disruptions in multiple cellular systems. Thus, while each disease...

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Concurrent regulation of the transcription factors Nrf2 and ATF4 mediates the enhancement of glutathione levels by the flavonoid fisetin.

Glutathione (GSH) and GSH-associated metabolism provide the major line of defense for the protection of cells from various forms of...

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