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Proton pump inhibitors enhance intestinal permeability via dysbiosis of gut microbiota under stressed conditions in mice.

Background: Intestinal permeability and psychological stress are considered the key mechanism(s) in functional dyspepsia (FD). Although proton pump inhibitors (PPIs)...

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Human Intestinal Barrier: Effects of Stressors, Diet, Prebiotics, and Probiotics.

The objectives of this article are to understand the effects of stressors (nonsteroidal antiinflammatory drug, exercise, and pregnancy) and components...

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Why is SARS-CoV-2 infection more severe in obese men? The gut lymphatics - Lung axis hypothesis.

Consistent observations report increased severity of SARS-CoV-2 infection in overweight men with cardiovascular factors. As the visceral fat possesses an...

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Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiological stress.

The magnitude, temporal dynamics, and physiological effects of intestinal microbiome responses to physiological stress are poorly characterized. This study used...

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Immune Function and Micronutrient Requirements Change over the Life Course.

As humans age, the risk and severity of infections vary in line with immune competence according to how the immune...

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Intestinal Barrier Function in Gluten-Related Disorders.

Gluten-related disorders include distinct disease entities, namely celiac disease, wheat-associated allergy and non-celiac gluten/wheat sensitivity. Despite having in common the...

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Intestinal permeability in humans is increased after radiation therapy.

Purpose: Irradiation inflicts acute injuries to the intestinal mucosa with rapid apoptosis induction and subsequent reduction in epithelial surface area....

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Effect of chemotherapy with 5-fluorouracil on intestinal permeability and absorption in patients with advanced colorectal cancer.

5-Fluorouracil (5-FU), in association with leucovorin (LV), is the most used chemotherapy agent in the treatment of colorectal cancer. Response...

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High salt diet exacerbates colitis in mice by decreasing Lactobacillus levels and butyrate production.

Background: Changes in hygiene and dietary habits, including increased consumption of foods high in fat, simple sugars, and salt that...

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