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MitoTox: a comprehensive mitochondrial toxicity database.

Background: Mitochondria play essential roles in regulating cellular functions. Some drug treatments and molecular interventions have been reported to have...

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Mitochondria and arrhythmias.

Mitochondria are essential to providing ATP, thereby satisfying the energy demand of the incessant electrical activity and contractile action of...

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Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy.

Heart disease is a leading cause of death worldwide. In many forms of heart disease, including heart failure, ischaemic heart...

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Mitochondrial dysfunction in pathophysiology of heart failure.

Mitochondrial dysfunction has been implicated in the development of heart failure. Oxidative metabolism in mitochondria is the main energy source...

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Mitochondrial Dynamics: Pathogenesis and Therapeutic Targets of Vascular Diseases.

Vascular diseases, particularly atherosclerosis, are associated with high morbidity and mortality. Endothelial cell (EC) or vascular smooth muscle cell (VSMC)...

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Mitochondrial cardiomyopathy and related arrhythmias.

Mitochondrial dysfunction has been shown to be involved in the pathophysiology of arrhythmia, not only in inherited cardiomyopathy due to...

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Inside the pathophysiological mechanisms of cardiometabolic diseases: the other pandemic to fight.

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in patient with metabolic disorders like type 2 diabetes,...

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Mitochondrial Dysfunction in Vascular Wall Cells and Its Role in Atherosclerosis.

Altered mitochondrial function is currently recognized as an important factor in atherosclerosis initiation and progression. Mitochondrial dysfunction can be caused...

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Alzheimer's Disease, Sleep Disordered Breathing, and Microglia: Puzzling out a Common Link. Cells.

Sleep Disordered Breathing (SDB) and Alzheimer's Disease (AD) are strongly associated clinically, but it is unknown if they are mechanistically...

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