Inside the pathophysiological mechanisms of cardiometabolic diseases: the other pandemic to fight.

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in patient with metabolic disorders like type 2 diabetes, metabolic syndrome, and obesity [7]. Therefore, it is especially important not only to make an early diagnosis of this entity but even more relevant is to achieve an early prevention of cardiometabolic disease due to its impact on public health. A several numbers of reasons lead to cardiometabolic disease becoming more frequent worldwide, such as clinical inertia, poor therapeutic approach, adverse effects associated with intensive control, inefficient strategies with old drugs, or the lack of control of other risk factors. However, a key factor is the lack of knowledge of the pathophysiological mechanisms that lead to this malady. Elucidating these mechanisms will allow a better comprehensive as well as personalized approach to cardiometabolic disease.