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Longitudinal changes in regional cerebral blood flow in late middle-aged and older adults with treated and untreated obstructive sleep apnea.

Obstructive sleep apnea (OSA) is associated with abnormal cerebral perfusion at wakefulness, but whether these anomalies evolve over time is...

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Obstructive Sleep Apnea and the Brain: a Focus on Gray and White Matter Structure.

Purpose of review: Obstructive sleep apnea is extremely prevalent in the elderly and may precipitate dementia. We review recent advances...

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Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction.

Breathing-disordered states, such as in obstructive sleep apnea, which are cyclical in nature, have been postulated to induce neurocognitive morbidity...

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Signs of Chronic Hypoxia Suggest a Novel Pathophysiological Event in α-Synucleinopathies.

Background: Multiple system atrophy (MSA) and Parkinson's disease (PD) patients develop respiratory and cardiovascular disturbances including obstructive sleep apnea, orthostatic...

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The Relationship between Obstructive Sleep Apnea and Alzheimer's Disease.

Obstructive sleep apnea (OSA) and Alzheimer's disease (AD) are highly prevalent conditions with growing impact on our aging society. While...

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Sleep-disordered breathing, brain volume, and cognition in older individuals with heart failure.

Background and purpose: Sleep-disordered breathing is common in individuals with heart failure and may contribute to changes in the brain...

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Chronic intermittent hypoxia-induced mitochondrial dysfunction mediates endothelial injury via the TXNIP/NLRP3/IL-1β signaling pathway.

Oxidative stress and inflammation induced by chronic intermittent hypoxia (CIH) are trigger factors of cardiovascular diseases in patients with obstructive...

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Can mitochondrial dysfunction be a predictive factor for oxidative stress in patients with obstructive sleep apnea?

Mitochondrial dysfunction reflects a lifelong cumulative burden of cellular damage, and a decrease in mitochondrial DNA (mtDNA) copy number is...

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Abnormal mitochondria organization and oxidative activity in the palate muscles of long-term snorers with obstructive sleep apnea

Background: Histopathological alterations and a reduced number of capillaries have been observed in the palate muscles of snorers with obstructive...

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