HEALTH NEWS
Study Title:
Protective effect of pyrroloquinoline quinone against Abeta-induced neurotoxicity in human neuroblas
Study Abstract
The neurotoxicity of aggregated beta-amyloid (Abeta) has been implicated as a critical cause in the pathogenesis of Alzheimer's disease (AD). It can cause neurotoxicity in AD by evoking a cascade of oxidative damage-dependent apoptosis to neurons. In the present study, we for the first time investigated the protective effect of pyrroloquinoline quinone (PQQ), an anionic, water soluble compound that acts as a redox cofactor of bacterial dehydrogenases, on Abeta-induced SH-SY5Y cytotoxicity. Abeta(25-35) significantly reduced cell viability, increased the number of apoptotic-like cells, and increased ROS production. All of these phenotypes induced by Abeta(25-35) were markedly reversed by PQQ. PQQ pretreatment recovered cells from Abeta(25-35)-induced cell death, prevented Abeta(25-35)-induced apoptosis, and decreased ROS production. PQQ strikingly decreased Bax/Bcl-2 ratio, and suppressed the cleavage of caspase-3. These results indicated that PQQ could protect SH-SY5Y cells against beta-amyloid induced neurotoxicity.
Study Information
Protective effect of pyrroloquinoline quinone against Abeta-induced neurotoxicity in human neuroblastoma SH-SY5Y cells
Neurosci Lett.
2009 October
Full Study
http://www.ncbi.nlm.nih.gov/pubmed/19699263Recent News
Protect Your Gut Mucosal Barrier for Immune Health and Vitality
The Truth About Sugar Substitutes: Are Stevia, Sucralose, and Saccharin Safe?
Boost Your Digestive Power for Better Nutrient Absorption and Gut Health
MTHFR Gene and The Importance of Methyl B12 and Methyl Folate
Do You Need a Multivitamin? What Science Says About Brain Health and Memory