HEALTH NEWS

Study Title:

MITOCHONDRIAL DNA MUTATIONS IN HUMAN DISEASE

Study Abstract

The human mitochondrial genome is extremely small compared with the nuclear genome, and mitochondrial genetics presents unique clinical and experimental challenges. Despite the diminutive size of the mitochondrial genome, mitochondrial DNA (mtDNA) mutations are an important cause of inherited disease. Recent years have witnessed considerable progress in understanding basic mitochondrial genetics and the relationship between inherited mutations and disease phenotypes, and in identifying acquired mtDNA mutations in both ageing and cancer. However, many challenges remain, including the prevention and treatment of these diseases. This review explores the advances that have been made and the areas in which future progress is likely.

Study Information


MITOCHONDRIAL DNA MUTATIONS IN HUMAN DISEASE
Nat Rev Genet.
2005 May

Full Study

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762815/
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