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Study Title:
Micronutrients intake is associated with improved sperm DNA quality in older men
Study Abstract
OBJECTIVE:
To investigate whether lifestyle factors such as increased dietary intake of micronutrients reduce the risks of sperm DNA damage, and whether older men benefit more than younger men.
DESIGN:
Cross-sectional study design with equalized assignments into age groups.
SETTING:
National laboratory and university.
PATIENT(S):
Nonclinical group of 22-80-year-old nonsmoking men (n = 80) who reported no fertility problems.
MAIN OUTCOME MEASURE(S):
Sperm DNA damage measured by alkaline and neutral DNA electrophoresis (i.e., sperm Comet assay).
RESULT(S):
Sociodemographics, occupational exposures, medical and reproductive histories, and lifestyle habits were determined by questionnaire. The average daily dietary and supplement intake of micronutrients (vitamin C, vitamin E, b-carotene, zinc, and folate) was determined using the 100-item Modified Block Food Frequency Questionnaire (FFQ). Men with the highest intake of vitamin C had approximately 16% less sperm DNA damage (alkaline sperm Comet) than men with the lowest intake, with similar findings for vitamin E, folate, and zinc (but not β-carotene). Older men (>44 years) with the highest vitamin C intake had approximately 20% less sperm DNA damage compared with older men with the lowest intake, with similar findings for vitamin E and zinc. The older men with the highest intake of these micronutrients showed levels of sperm damage that were similar to those of the younger men. However, younger men (<44 years) did not benefit from higher intakes of the micronutrients surveyed.
CONCLUSION(S):
Men with higher dietary and supplement intake of certain micronutrients may produce sperm with less DNA damage, especially among older men. This raises the broader question of how lifestyle factors, including higher intakes of antioxidants and micronutrients, might protect somatic as well as germ cells against age-associated genomic damage.
From press release:
A new study led by scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) found that a healthy intake of micronutrients is strongly associated with improved sperm DNA quality in older men. In younger men, however, a higher intake of micronutrients didn't improve their sperm DNA.
In an analysis of 80 healthy male volunteers between 22 and 80 years of age, the scientists found that men older than 44 who consumed the most vitamin C had 20 percent less sperm DNA damage compared to men older than 44 who consumed the least vitamin C. The same was true for vitamin E, zinc, and folate.
"It appears that consuming more micronutrients such as vitamin C, E, folate and zinc helps turn back the clock for older men. We found that men 44 and older who consumed at least the recommended dietary allowance of certain micronutrients had sperm with a similar amount of DNA damage as the sperm of younger men," says Andy Wyrobek of Berkeley Lab's Life Sciences Division.
"This means that men who are at increased risk of sperm DNA damage because of advancing age can do something about it. They can make sure they get enough vitamins and micronutrients in their diets or through supplements," adds Wyrobek.
Wyrobek conducted the research with a team of researchers that includes Brenda Eskenazi of the University of California at Berkeley's School of Public Health and scientists from the University of Bradford in the United Kingdom. They report their findings in the August 27 online issue of the journal Fertility and Sterility.
Their research comes as more men over 35 have children, which raises public health concerns. Previous research conducted in Wyrobek's lab found that the older a man is, the more he's likely to have increased sperm DNA fragmentation, chromosomal rearrangements, and DNA strand damage. Older men are also more likely to have increased frequencies of sperm carrying certain gene mutations, such as those leading to dwarfism. These findings help explain why aging men are less fertile and are predicted to have more chromosomally defective pregnancies and a higher proportion of offspring with genetic defects.
But until now, researchers haven't understood whether diet can protect against the detrimental effects of aging on the sperm genome.
The scientists studied a group of about 80 men between 20 and 80 years old with an average age of 44. They were recruited several years ago as part of the California Age and Genetic Effects on Sperm Study when Wyrobek was at Lawrence Livermore National Laboratory. Each man who participated in the study filled out a 100-item questionnaire that estimated their average daily vitamin intake, both from food and supplements.
In addition, their sperm DNA quality was assessed via a lab analysis in which a voltage gradient pulls broken DNA strands from intact strands within the sperm nucleus.
Each volunteer's intake of a micronutrient was classified as low, moderate, or high based on how they compared to other participants. The median daily intake, both from diet and supplements, was 162 milligrams for vitamin C, 23.7 milligrams for vitamin E, 2,586 micrograms for β-carotene, 475 grams for folate, and 12.3 milligrams for zinc. Many participants, even those who reported to be healthy, consumed much less than the recommended dietary allowance for many of the micronutrients.
The scientists analyzed the data several ways and came up with the same result each time: A diet high in antioxidants and micronutrients may decrease the risk of producing sperm with DNA damage, especially in older men.
Why this is so isn't a mystery. Antioxidants scavenge reactive molecules that cause oxidative damage to cells. Studies have shown that dietary supplementation with antioxidants and increased consumption of antioxidant-rich fruits and vegetables can decrease the amount of oxidative DNA damage.
Based on their results, the scientists believe this same protective mechanism may also be at work in the reproductive tract of older men.
"The different response of the old and young men presents new opportunities for health care, especially for older men planning families," says Wyrobek.
More research is needed, however. Although the scientists found a clear link between higher vitamin intake and improved sperm DNA quality in older men, they don't know whether this link extends to male fertility and the health of offspring.
"Our research points to a need for future studies to determine whether increased antioxidant intake in older fathers will improve fertility, reduce risks of genetically defective pregnancies, and result in healthier children," says Wyrobek. "The research also raises a broader question beyond sperm DNA: How might lifestyle factors, including higher intakes of antioxidants and micronutrients, protect somatic as well as germ cells against age-related genomic damage?"
Study Information
Schmid TE, Eskenazi B, Marchetti F, Young S, Weldon RH, Baumgartner A, Anderson D, Wyrobek AJ.Micronutrients intake is associated with improved sperm DNA quality in older men
Fertil Steril.
2012 August
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California; Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, California.
