Leptinal® is our premier cardiovascular and weight management support supplement. It contains a potent array of heart-friendly nutrients, all in one softgel capsule. Formulated with mercury-free DHA in the TG form, a special pomegranate extract, borage oil, and a unique combination of citrus-polyflavones and tocotrienols.*

The Leptinal Quality Difference

• Premium Quality Fish Oil: Mercury-free omega-3 fish oil DHA, molecularly distilled to ensure purity without the risk of heavy metals or chemical residues.
• Natural Triglyceride (TG) Form: Fish oil that won't oxidize within the capsule, preserving its integrity and free from soy and rancid oils.
• Powerful Antioxidants: Includes standardized pomegranate extract and tocotrienols, the most potent form of vitamin E, to offer enhanced cardiovascular protection.*
• GLA from Borage Oil: High purity omega oil for arterial and blood pressure health.*

Weight Management

Leptinal® is designed to reduce metabolic stress from fat cells and support normal fat metabolism. DHA helps lower excess leptin production and activates signals to break down stored fat (UCP2). It also promotes a gene in muscles (UCP3) that helps burn fat for energy, especially during exercise.*

Punicalagins from pomegranate naturally regulate cellular stress, which is essential for healthy metabolism. The punicalagins of pomegranate are a nutritional tool the body may use to naturally regulate stressful cellular signals. Too much cellular stress interferes with metabolic signals needed for healthy metabolism.

Leptinal® is a synergistic combination of nutrients that work to improve the fitness of your fat cells and support weight management. Research shows a combination of DHA, nobiletin, and tangeretin support weight management by promoting healthier fat cells that store less fat and resist expansion. These nutrients also help fat cells produce adiponectin, a hormone vital for proper insulin function.*

Supporting Thyroid Function

Leptinal® supports thyroid function by helping to balance leptin. Proper leptin entry into the brain is essential for triggering thyroid hormone production, but high triglyceride levels can interfere with this process. Nutrients like DHA and citrus polyflavanoids in Leptinal® help promote healthy triglyceride levels, ensuring leptin can enter the brain properly.*

Thyroid hormone activation also occurs in the liver, where DHA, GLA, and tocotrienols strengthen cell membranes. This supports the normal activation of thyroid hormone, which works with DHA to activate genes that promote natural fat burning.*

Healthy Bones and Nerves

DHA accumulates in bones and is essential for their healthy structure and function. Tocotrienols support bone formation, making bone health important during any weight management program.*

Protecting brain cells is vital since they don’t regenerate like other cells. Alpha tocotrienol, a form of vitamin E, is easily absorbed into nerve cell membranes and acts as a powerful antioxidant. Animal studies suggest that pomegranate's antioxidants also protect the nervous system.*

Blood Pressure

DHA supports healthy arterial structure and flexibility, which enhances blood flow and heart function. GLA, another key component, helps build healthy cell membranes, including those in arteries.*

DHA and GLA also support the production of beneficial prostaglandins (PGE3 and PGE1) that help regulate blood pressure and circulation. Since these essential fatty acids are often lacking in the American diet, supplementation with Leptinal® is a convenient way to increase your intake.*

Our pomegranate extract, rich in punicalagins, provides powerful antioxidants that protect the cardiovascular system. Tocotrienols also support healthy circulation and the lining of blood vessels.*

Healthy Cholesterol Levels

Maintaining healthy cholesterol levels naturally is vital for cardiovascular health. This requires eating a balanced diet, limiting fat and sugar intake, and exercising regularly. Leptinal® complements a healthy lifestyle to help you maintain healthy cholesterol levels.*

Sytrinol™, with citrus compounds tangeretin and nobiletin, supports healthy LDL cholesterol levels by modulating the production of apo-B and triglycerides. Human clinical trials show Sytrinol™ helps maintain healthy cholesterol levels, including HDL. In softgels containing DHA and tocotrienols, Sytrinol™ is four times better absorbed than in a plain powder capsule.*

Leptinal® also includes tocotrienols from palm fruit and rice bran oil. Alpha tocotrienol is a strong antioxidant that protects circulation and nerves, while gamma tocotrienol helps maintain normal cholesterol levels.*

GLA and DHA in Leptinal® support the formation of HDL cholesterol and overall metabolism of cholesterol and triglycerides.*

The FDA allows the following claim: Supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease.

The Power of Leptin

Leptin is a hormone produced mainly by fat cells in white adipose tissue. It travels through the blood to the brain, where it regulates key metabolic signals involved with energy production, cholesterol synthesis, thyroid function, liver and pancreatic function, and bone formation. Proper leptin function is crucial for effective weight management, as it ensures smooth communication between fat cells, the brain, liver, and pancreas.

Just like muscles can get out of shape, white adipose tissue can become less effective over time. Enlarged fat cells struggle to release stored fat and may start producing stress signals that complicate weight management. Disrupted leptin communication can lead to metabolic stress and weight management challenges.

The big question of the twenty-first century is: How fit is your fat? The Leptin Diet book explains how to eat to be in harmony with leptin, vital information for healthy weight management.*

Leptinal® offers a powerful blend of nutrients to improve leptin hormone communication with the brain.*