HEALTH NEWS

Study Title:

Leptin and Thyroid Cancer

Study Abstract

Leptin is a multifunctional adipose-derived cytokines that play a critical role in bodyweight homeostasis and energy balance. Recently, leptin and leptin receptor dysreulation have been reported in variety of malignant cells including thyroid. Leptin modulates growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT and/or Map kinases. In this review, current understanding of leptin's role in the pathogenesis of thyroid cancer has been described.

Study Information

Uddin S, Hussain AR, Siraj AK, Khan OS, Bavi PP, Al-Kuraya KS
Role of leptin and its receptors in the pathogenesis of thyroid cancer
Int J Clin Exp Pathol.
2011 October
Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center Riyadh, Saudi Arabia.