Quercetin Phytosome + Luteolin

Advanced Absorption Flavonoids

18 total reviews

Quercetin Phytosome + Luteolin supports immune, respiratory, and normal inflammatory response. It features Quercefit® Quercetin phytosome for superior bioavailability and luteolin for added antioxidant and neuroprotective benefits. Science-based, highly effective daily flavonoid support.*

Size: 60 capsules

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Supports
Immune Support Longevity Supplements Stress & Mood Thyroid & Metabolism
Key Nutrients
Quercetin
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Manufactured in USA & Third-Party Tested


Why Choose This Formula?

20x Quercetin Absorption

20x Quercetin Absorption

Quercefit® binds quercetin to sunflower-derived phospholipids, providing up to 20x greater bioavailability than standard quercetin so your body can absorb and use it more effectively.*

Dual Flavonoid Support

Dual Flavonoid Support

Quercetin and luteolin work together to support mast cell stability, healthy histamine release, immune balance, and respiratory comfort.*

Cellular Energy & Longevity

Cellular Energy & Longevity

Beyond immune support, quercetin and luteolin help protect brain and nerve cells while supporting NAD+, mitochondrial function, and healthy cellular aging.*

At a Glance

  • Supports healthy immune and histamine response*
  • Promotes sinus, lung, and respiratory comfort*
  • Provides antioxidant and neuroprotective support*
  • Supports NAD+, mitochondria, and healthy cellular aging*

Is This Right for You?

  • Support a healthy histamine and mast cell response*
  • Maintain immune balance during seasonal or environmental stress*
  • Promote sinus, lung, and respiratory comfort*
  • Add antioxidant protection for brain and nerve cells*
  • Support NAD+, mitochondrial function, and healthy cellular aging*

Common Questions

What makes Quercetin Phytosome + Luteolin different from standard quercetin?

Quercefit® Quercetin Phytosome binds quercetin to sunflower-derived phospholipids to improve absorption. Research on this delivery system has shown up to 20x greater bioavailability than standard quercetin.*

Why combine quercetin and luteolin?

Quercetin and luteolin are complementary flavonoids that support antioxidant defenses, immune signaling, mast cell stability, histamine balance, and healthy inflammatory response through overlapping but distinct pathways.*

How do quercetin and luteolin support histamine balance?

Both nutrients help stabilize mast cells, the immune cells that release histamine. Supporting healthy mast cell activity helps maintain a balanced response to seasonal and environmental irritants.*

How does this formula support NAD+?

Quercetin and luteolin help regulate CD38, an enzyme involved in NAD+ breakdown. Supporting healthy CD38 activity helps maintain NAD+ needed for mitochondrial energy and normal cellular function.*

What is a phytosome?

A phytosome combines a plant nutrient with phospholipids to improve solubility, absorption, and delivery. Quercefit® uses this technology to make quercetin substantially more bioavailable than standard forms.*

Dual Flavonoid Power: Bioactive Quercetin + Luteolin

How It Works

Quercetin Phytosome + Luteolin

This advanced formula delivers two of nature's most powerful flavonoids in one highly absorbable, science-backed supplement. Quercetin and Luteolin, both derived from the Sophora japonica flower, offer complementary benefits for maintaining immune strength, a healthy inflammatory response, and respiratory resilience.*

Unlike standard quercetin, Quercefit® Quercetin Phytosome is bound to sunflower-derived phospholipids for 20x higher bioavailability, ensuring your body can absorb and use it effectively. We added Luteolin for synergistic immune boost and histamine support.*

Key Benefits:

  • Immune System Support – Helps regulate immune signaling and cytokine response*
  • Inflammatory Balance - Supports natural inflammation-modulating pathways*
  • Respiratory Health - Promotes sinus, lung, and airway comfort*
  • Antioxidant Protection - Shields cells from oxidative stress*
  • Neuroprotective Support - Offers support for brain and nerve health*
  • NAD+ Support - Helps maintain NAD+ levels and support mitochondria*

Immune Support and Allergy Relief

Both Quercetin and Luteolin have wide-ranging effects that support immunity and provide relief to allergy sufferers. These flavonoids stabilize mast cells to regulate histamine release, support immune cell function, and promote healthy inflammatory response, especially in the respiratory tract.*

Cognitive Support and Neuroprotection

Provides antioxidant protection, neutralizes free radicals, supports brain and nerve health, and calms glial cells to enhance mental clarity, mood, and stress tolerance.*

NAD Support

Quercetin and Luteolin are two of the most potent inhibitors of the NAD-depleting enzyme CD38. This helps maintain NAD+ levels, supporting mitochondrial function, energy, and overall health.*

Longevity Supplement

Quercetin and Luteolin work together to reduce cellular senescence, up-regulate sirtuins, and provide antioxidant support, all which support healthy cellular aging.*

Ingredients & Directions

How To Take

Take 1 capsule, up to two times per day.

Supplement Facts

Serving Size: 1 Capsule
Amount Per Serving % Daily Value
Quercefit® Quercetin Phytosome (Sophora japonica L. extract (flower) and sunflower phospholipid complex) (standardized to contain 34% quercetin) 250 mg *
Luteolin (from Sophora japonica L. extract) (flower) 100 mg *

* Daily Value not established

Other Ingredients: cellulose capsule, cellulose, and magnesium stearate.

This product does NOT contain: milk, egg, fish, Crustacean shellfish, tree nuts, peanuts, wheat, gluten, soy, or sesame. This product does not contain hidden fillers, preservatives, sugar, artificial sweeteners, colors, or flavors.

Manufactured in the USA

We source the highest quality, most absorbable nutrients. Our supplements are manufactured in the United States under stringent quality standards.

Third-Party Tested

Wellness Resources supplements are tested throughout production for potency and purity. Each final batch is tested to ensure you are getting what's on the label.

Family-Owned Since 1985

Our specialty formulas are backed by science and years of experience. Made with care, from our family to yours. A supplement line you can trust.

Customers praised this supplement for its enhanced absorption with Quercefit phytosome formula and effectiveness for allergies, sinusitis, and histamine control. Many noted "excellent antioxidant" properties and natural ingredients. Some concerns about price point and fillers, with a few mentioning it's expensive compared to alternatives.

  • 5 stars: 12 (67%)
  • 4 stars: 6 (33%)
  • 3 stars: 0 (0%)
  • 2 stars: 0 (0%)
  • 1 star: 0 (0%)
K
K.A.
Seems like a good supplement

My daughter and I both take quercetin as a supplement, especially in spring and summer when pollen is making us extra sneezy. This seems to work about as effectively as any other kind that we’ve tried, and we’ve had no issues with the quality of it although it is noticeably paler than others we’ve used.Quercetin is said to have a lot of health benefits and we have found it helpful. In terms of value this is one of the more expensive ones that we’ve tried and I’m not sure it’s worth the additional cost.

2
Quecertin Phytosome with Luteolin

I just have to tell you about the Wellness Resources supplement featuring Quercetin Phytosome and Luteolin. This is a highly specialized blend designed for broad cellular and general well-being support, focusing on maximizing nutrient absorption. This formula pairs Quercetin Phytosome with Luteolin. The Quercetin is delivered in a form called Quercefit, which is a bioactive phytosome preparation. This is important because it makes the quercetin about 20 times more absorbable than standard quercetin powder, so it is a great value. The combination of these two flavonoids is designed for comprehensive internal balance. They are designed to work together to reduce age related cellular stress and assist in maintaining levels of NAD+ (Nicotinamide Adenine Dinucleotide), which is important for energy and overall cellular health. They also provide significant antioxidant protection to help the body neutralize free radicals and support nerve health. This product comes in a capsule form, is unflavored, and is suitable for both gluten free and vegetarian diets. It is highly concentrated, offering these two powerful bioflavonoids in a more absorbable and effective way. As with all supplements, it is advised to consult a physician prior to taking.

P
Plant Mom
Natural histamine support

This is a natural antihistamine and transports zinc ions across cell membranes that enhances zinc concentration in the cell. This is effective and a natural histamine support.

S
Steve Cekalla

Reformulated for better absorption An excellent antioxidant

G
Greg Truesdell

So far everything‘s good

D
Deb Bergeron

Love it!

S
Sandye Garcia

It keeps me well & my sinusitis in check

J
J. Roberts
So far, so good

This seems to be a good quality quercetin so far.- Capsules are easy to swallow- No odd aftertaste or ill effects- Price/Value is rather expensive for quercetin- Label has GMP stamp and claims 3rd party lab tested (however I haven't seen the COA yet)I haven't had any problem taking these, but I'm only giving 4 stars for now until I have a chance to view a COA from the company for this product. If/when I receive that, I'll revise my review accordingly.

T
T. Ellison
A good histamine controlling supplement!

Made in USA! So, to start off with, this is a supplement developed and packaged in the US. Doing some basic research, you can determine the facility that does the research and packaging of this product. For a good cell stabilizer and histamine this supplement is awesome. I live with severe allergies to environmental, seasonal allergies, and this reallly help me. I have gone this whole season without taking nasty antihistamines. I am very happy with this supplement and will definitely look at a long-term application since it's cheaper than some OTC meds.

A
Amazon Customer
Wellness Tablets

Easy to swallow and use. The pills are larger, but not too bad. It has natural ingredients in it and a good health benefits.Good value for the money

m
mm
Good

This quercetin supplement by Wellness Resources is good so far. I like using quercetin for it's many benefits (I'm not able to list them here) and I found this one to be effective. I like that it's made in the USA. I think for the price, it should have less fillers. I am actively trying to find supplements that have less fillers like cellulose and magnesium stearate, so that's why I removed a star. Overall, this is decent.

T
Tesla Starr
Unique formulation of Quercetin and Luteolin offers improved absorption for the body.

The bottle of 60 vegan capsules is very well sealed and according to the supplement facts on the label each one contains 250 mg. Quercefit (registered trademark of Italy) Quercetin Phytosome (standardized to contain 34% quercetin). It also contains 100 mg. of Luteolin in the form of an extract (flower). There is a lot number plus expiration date of 03/27 along with a website and MN distribution address. The directions indicate 1 capsule up to 2 times daily may be taken and notes this Quercetin Phytosome Luteolin supplement contains advanced absorption for immune health, neuroprotection and mitochondrial support.I'm a fan of Quercetin/bioflavonoids and like to keep it on hand for a boost to the immune system as needed and find this formulation with Luteolin intriguing in terms of possible health benefits. It's a much lower amount of Quercetin than I would normally take per capsule; however, research indicates Luteolin may be a powerful antioxidant with its own particular benefits so am going to give it a try and see.

M
Maria
Researched-back dosage from a brand I've had good experiences with in the past

Wellness Resources is a brand I have tried before and trust as a result (I use their D-Limonene softgels to help with indigestion), so I was quite pleased to order their Quercetin and Luteolin complex.Quercetin is usually taken at 500-1000mg per day. This supplement gives 250mg per pill, to be taken up to twice a day. Luteolin dosage can range from 50-300mg per day, and this supplement falls within that range at 100mg per pill. Luteolin can be rather expensive, and this product is right around where I would expect for something containing 100mg per pill - $33.97, at the time of this writing.I started with one pill per day to assess tolerance, and as I had no negative reactions or digestive upset, moved to 2x per day without issue. The pills are somewhat on the larger side, but not so big as to be difficult to swallow. There is no noticeable taste, odor, or aftertaste to my senses.I think that, if you are looking for a solid Quercetin and Luteolin supplement to add to your longevity routine, this is a great choice. As I've mentioned, I've had great results from their other products, so I trust the Wellness Resources brand to provide what they advertise. Their price point also makes sense for the ingredients included.

P
Persnickety
Price per dose is high, but the quality is very good.

My overall impression of this supplement is that it is easy to take, the pills are average sized with no particularly bad flavor. Long term effectiveness is hard to judge but in the short term the have been helping with allergy relief.Strengths:Phytosome formulation: The "Quercefit" version claims ~20x better absorption than standard quercetin. That's important—quercetin has poor bioavailability otherwise.Luteolin pairing: A smart combo. Luteolin complements quercetin in mast cell stabilization and neuroinflammation support.Broad support claims: Covers allergies, inflammation, NAD+ preservation, and neuroprotection—reasonable, given the roles of these flavonoids.Good quality control: Third-party tested, U.S.-made, and avoids common allergens and additives.Cautions:High price per dose: $0.57 per capsule, and it's likely taken twice daily for full effect—so about $34/month.Cellular aging/NAD support: These claims are mechanistically plausible but not yet well proven in humans.Summary:This is a high-quality flavonoid supplement, likely better absorbed than many cheaper quercetin products. It’s a good option for allergy support, mild neuroinflammation, or mitochondrial/NAD-related regimens. Worth considering if you're targeting those areas and don’t mind the price to get the quality.

S
Sunshine Tibbs
Miracle supplement!

While I can’t say I feel smarter, I definitely feel more focused! There’s so many benefits that you probably won’t notice right away. They are easy to swallow and moderate in size. For a supplement of this caliber it’s a good value.

C
C. Banker
Quercetin

Good value

T
Talk2bethany
Very effective for hives

This item has really improved my urticaria and allowed me to reduce my reliance on Zyrtec.

A
Anonymous

I feel positive about continuing to take it