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Effects of surgery and anesthetic choice on immunosuppression and cancer recurrence.

BACKGROUND:The relationship between surgery and anesthetic-induced immunosuppression and cancer recurrence remains unresolved. Surgery and anesthesia stimulate the hypothalamic-pituitary-adrenal (HPA) axis...

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Morphine Promotes Tumor Angiogenesis and Increases Breast Cancer Progression.

Morphine is considered a highly potent analgesic agent used to relieve suffering of patients with cancer. Several in vitro and...

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Herpes labialis in parturients receiving epidural morphine following cesarean section.

A significant association exists between the use of epidural morphine (EM), reactivation of herpes labialis (HL) commonly known as coldsores,...

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Use of opioids or benzodiazepines and risk of pneumonia in older adults: a population-based case-control study.

OBJECTIVES:To examine whether use of opioids or benzodiazepines is associated with risk of community-acquired pneumonia in older adults.DESIGN:Population-based case-control study.SETTING:An...

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Morphine enhances HIV-1SF162-mediated neuron death and delays recovery of injured neurites.

HIV-1 enters the CNS soon after initial systemic infection; within the CNS parenchyma infected and/or activated perivascular macrophages, microglia and...

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Opioids and Viral Infections: A Double-Edged Sword.

Opioids and their receptors have received remarkable attention because they have the ability to alter immune function, which affects disease...

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Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model.

Opioid analgesics are frequently prescribed in the United States and worldwide. However, serious comorbidities, such as dependence, tolerance, immunosuppression and...

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Opioids and the immune system - friend or foe.

Systemically administered opioids are among the most powerful analgesics for treating severe pain. Several negative side effects (respiratory depression, addiction,...

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Functions of natural killer cells.

Natural killer (NK) cells are effector lymphocytes of the innate immune system that control several types of tumors and microbial...

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