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FDA requires strong warnings for opioid analgesics, prescription opioid cough products, and benzodiazepine labeling related to serious risks and death from combined use.

After an extensive review of the latest scientific evidence, the U.S. Food and Drug Administration announced today that it is...

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Our Other Prescription Drug Problem.

The epidemic of opioid addiction and overdose has appropriately garnered national attention and led to concerted efforts to reduce overprescribing...

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Dangers of rising benzo prescriptions raise alarms of next drug crisis.

When Christy Huff developed a painful eye problem that led to insomnia, her doctor had a common solution— Xanax. She...

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Anti-cholinergic drugs and memory: the effects of benzhexol on memory in a group of geriatric patients.

A double blind trial on the effects of 2 mg of benzhexol on memory was performed on thirteen elderly subjects...

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Paul Montgomery Jennifer R. Burton Richard P. Sewell Thees F. Spreckelsen Ale

Fatty acids and sleep in UK children: subjective and pilot objective sleep results from the DOLAB study – a randomized controlled trial

Sleep problems in children are associated with poor health, behavioural and cognitive problems, as are deficiencies of long‐chain omega‐3 fatty...

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The Glymphatic System and Waste Clearance with Brain Aging: A Review.

The glymphatic system is a glial-dependent waste clearance pathway in the brain, in place of lymphatic vessels, dedicated to drain...

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Zinc ions regulate opening of tight junction favouring efflux of macromolecules via the GSK3β/snail-mediated pathway.

Zinc is an essential trace element presenting in particularly high concentration in the brain. In some regions, e.g. lateral amygdala,...

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Omega-3 polyunsaturated fatty acids promote amyloid-β clearance from the brain through mediating the function of the glymphatic system.

Impairment of amyloid-β (Aβ) clearance leads to Aβ accumulation in the brain during the development of Alzheimer's disease (AD). Strategies...

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Dual targeting agents for Aβ plaque/P-glycoprotein and Aβ plaque/nicotinic acetylcholine α4β2* receptors-potential approaches to facilitate Aβ plaque removal in Alzheimer's disease brain.

Alzheimer's disease (AD) affects 10% of people older than 65 and is characterized by a progressive loss of cognitive function...

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