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From Vitality to Vital Exhaustion and Other States of "Tense Tiredness": A New Biopsychosocial Risk Domain.

Fatigue is a common prodromal symptom for various medical conditions, including acute myocardial infarction. Fatigue is also the core component...

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Diurnal cortisol and alpha-amylase in the daily lives of older adults with vital exhaustion.

OBJECTIVE:Vital exhaustion (VE) is characterised by unusual fatigue, increased irritability, and a feeling of demoralisation. It has been found a...

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trans-Resveratrol in nutraceuticals: issues in retail quality and effectiveness.

Fourteen brands of resveratrol-containing nutraceuticals were evaluated in order to verify their actual resveratrol content and to control if their...

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Vinpocetine effects on cognitive impairments produced by flunitrazepam.

The effects of pre-treatment with vinpocetine 40 mg, on flunitrazepam-induced impairment of memory, were studied in 8 normal volunteers. Tests...

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Antinociceptive effects of fisetin against diabetic neuropathic pain in mice: Engagement of antioxidant mechanisms and spinal GABAA receptors.

Peripheral painful neuropathy is one of the most common complications in diabetes and necessitates improved treatment. Fisetin, a naturally occurring...

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GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence.

Anxiety disorders are chronic and functionally disabling conditions with high psychological stress, characterised by cognitive symptoms of excessive worry and...

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Effects of Melissa officinalis L. (lemon balm) extract on neurogenesis associated with serum corticosterone and GABA in the mouse dentate gyrus.

Lemon balm, leaves of Melissa officinalis L., has been used for anti-anxiety and spasmolytics. We observed the extract of Melissa...

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Magnesium in neuroses and neuroticism.

Neuroses are a frequently encountered group of psychiatric diseases with a symptomatology including neuronal hyperexcitability, anxiety, panic, phobic reactions, quite...

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Fatty Acid Regulation of Voltage- and Ligand-Gated Ion Channel Function.

Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate...

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