Catiele Antunes; Sean A. Curtis.
Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is a condition that develops when there is a retrograde flow of stomach contents causing symptoms...
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Mitochondrial Disease and Toxins.
Mitochondrial dysfunction has been identified as an important factor in many diseases and conditions beyond primary mitochondrial disease, including autism,...
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Powering the immune system: mitochondria in immune function and deficiency.
Mitochondria are critical subcellular organelles that are required for several metabolic processes, including oxidative phosphorylation, as well as signaling and...
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Mitochondria: commanders of innate immunity and disease?
Mitochondrial dysfunction is associated with the manifestation and origin of a plethora of diseases and disorders. Whilst classically the role...
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Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity.
Mitochondria contribute to cellular innate immunity against RNA viruses. Mitochondrial-mediated innate immunity is regulated by signalling molecules that are recruited...
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Cancer as a metabolic disease.
Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or...
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Exploring and exploiting the connection between mitochondria and the virulence of human pathogenic fungi.
Mitochondria are best known for their role in the production of ATP; however, recent research implicates other mitochondrial functions in...
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Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection.
Mitochondria are highly dynamic and structurally complex organelles that provide multiple essential metabolic functions. Mitochondrial dysfunction is associated with neurodegenerative...
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Mitochondria in the regulation of innate and adaptive immunity.
Mitochondria are well appreciated for their role as biosynthetic and bioenergetic organelles. In the past two decades, mitochondria have emerged...
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