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High dose folic acid supplementation in women with epilepsy: are we sure it is safe?

Most experts agree that folic acid supplementation is a key preconception intervention, particularly in women with epilepsy who take anti-epileptic...

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Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4-5 y of age: the prospective birth cohort Infancia y Medio Ambiente (INMA) study

Background: The benefits of the use of folic acid supplements (FASs) during the periconception period to prevent neural tube defects...

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Is folic acid good for everyone?

Fortification of food with folic acid to reduce the number of neural tube defects was introduced 10 y ago in...

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Folate and colorectal cancer: an evidence-based critical review.

Currently available evidence from epidemiologic, animal, and intervention studies does not unequivocally support the role of folate, a water-soluble B...

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Effect of folate oversupplementation on folate uptake by human intestinal and renal epithelial cells.

BACKGROUND:Folic acid [corrected] plays an essential role in cellular metabolism. Its deficiency can lead to neural tube defects. However, optimization...

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Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role.

DNA methylation is an epigenetic modification critical to normal genome regulation and development. The vitamin folate is a key source...

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Neural tube defects and periconceptional folic acid in England and Wales: retrospective studyCommentary: Food should be fortified with folic acid

Food fortification with folic acidKadir et al1 assessed changes in the incidence of neural tube defects(NTD) resulting from 1992 government...

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The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake.

Numerous clinical trials using folic acid for prevention of cardiovascular disease, stroke, cognitive decline, and neural tube defects have been...

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Unmetabolized serum folic acid and its relation to folic acid intake from diet and supplements in a nationally representative sample of adults aged > or =60 y in the United States.

BACKGROUND:Unmetabolized serum folic acid (UMFA) has been detected in adults. Previous research indicates that high folic acid intakes may be...

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