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Impact of neonatal iron deficiency on hippocampal DNA methylation and gene transcription in a porcine biomedical model of cognitive development.

BACKGROUND:Iron deficiency is a common childhood micronutrient deficiency that results in altered hippocampal function and cognitive disorders. However, little is...

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Cobalamin deficiency and subacute combined degeneration after nitrous oxide anesthesia: a case report.

We report on a diabetic man in his early forties with a history of disabling left-hemisphere stroke and hyperhomocystinemia who...

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Reduced DNA methylation and psychopathology following endogenous hypercortisolism – a genome-wide study

Patients with Cushing’s Syndrome (CS) in remission were used as a model to test the hypothesis that long-standing excessive cortisol...

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Crosstalk between the microbiome and epigenome: messages from bugs.

Mammals exist in a complicated symbiotic relationship with their gut microbiome, which is postulated to have broad impacts on host...

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An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training.

Regular endurance exercise training induces beneficial functional and health effects in human skeletal muscle. The putative contribution to the training...

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Lifelong physical activity is associated with promoter hypomethylation of genes involved in metabolism, myogenesis, contractile properties and oxidative stress resistance in aged human skeletal muscle.

Lifelong regular physical activity is associated with reduced risk of type 2 diabetes (T2D), maintenance of muscle mass and increased...

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Precision Physical Therapy: Exercise, the Epigenome, and the Heritability of Environmentally Modified Traits.

One of the newest frontiers of physical therapy is the field of epigenetics, which examines how pervasive environmental factors such...

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Slowing Down Ageing: The Role of Nutrients and Microbiota in Modulation of the Epigenome.

The human population is getting ageing. Both ageing and age-related diseases are correlated with an increased number of senescent cells...

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DNA methylation and its basic function.

In the mammalian genome, DNA methylation is an epigenetic mechanism involving the transfer of a methyl group onto the C5...

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