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Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism.

OBJECTIVE:Intestinal permeability and psychological stress have been implicated in the pathophysiology of IBD and IBS. Studies in animals suggest that...

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Risk factors associated with intestinal permeability in an adult population: A systematic review.

BACKGROUND:Increased intestinal permeability (IP) involves the loss of integrity between the cells of the small intestine. IP has been suggested...

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Oral supplementation with non-absorbable antibiotics or curcumin attenuates western diet-induced atherosclerosis and glucose intolerance in LDLR-/- mice--role of intestinal permeability and macrophage activation.

Association between circulating lipopolysaccharide (LPS) and metabolic diseases (such as Type 2 Diabetes and atherosclerosis) has shifted the focus from...

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Curcumin improves intestinal barrier function: modulation of intracellular signaling, and organization of tight junctions.

Association between circulating lipopolysaccharide (LPS) and metabolic diseases (such as type 2 diabetes and atherosclerosis) has shifted the focus from...

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Regulation of intestinal permeability: The role of proteases.

The gastrointestinal barrier is - with approximately 400 m2 - the human body's largest surface separating the external environment from...

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A Microcirculatory Theory of Aging.

Aging is the progressive decline of physiological functions necessary for survival and reproduction. In gaining a better understanding of the...

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Vitamin C revisited.

This narrative review summarizes the role of vitamin C in mitigating oxidative injury-induced microcirculatory impairment and associated organ failure in...

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Dry olive leaf extract ameliorates experimental autoimmune encephalomyelitis.

BACKGROUND & AIMS:Experimental autoimmune encephalomyelitis (EAE) is an animal model of CNS inflammatory and demyelinating disease multiple sclerosis. Mediterranean diet,...

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Role of mitochondrial dysfunction in hyperglycaemia-induced coronary microvascular dysfunction: Protective role of resveratrol.

Microvascular complications are now recognized to play a major role in diabetic complications, and understanding the mechanisms is critical. Endothelial...

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