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Evidence Refuting the Existence of Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA).

Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) was described in 2011. Over time the condition and its triggers have broadened to...

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Aluminum induced reversible change in permeability of the blood-brain barrier to [14C]sucrose.

To determine whether aluminum alters the permeability of the blood-brain barrier (BBB), 4 groups of rats were given an intraperitoneal...

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Myalgia and chronic fatigue syndrome following immunization: macrophagic myofasciitis and animal studies support linkage to aluminum adjuvant persistency and diffusion in the immune system.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a multifactorial and poorly undersood disabling disease. We present epidemiological, clinical and experimental evidence...

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'ASIA' - autoimmune/inflammatory syndrome induced by adjuvants.

The role of various environmental factors in the pathogenesis of immune mediated diseases is well established. Of which, factors entailing...

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Analysis of safety from a human clinical trial with pterostilbene.

OBJECTIVES:The purpose of this trial was to evaluate the safety of long-term pterostilbene administration in humans.METHODOLOGY:The trial was a prospective,...

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Biological actions and molecular effects of resveratrol, pterostilbene, and 3'-hydroxypterostilbene.

Stilbenes are a class of polyphenolic compounds, naturally found in a wide variety of dietary sources such as grapes, berries,...

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Sirtuin activators.

BACKGROUND:Sirtuin 1-7 (SIRT1-7) are deacetylases that are dependent on NAD(+) for their activity. SIRT1 down-regulates p53 activity, increasing lifespan, cell...

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Role of nrf2 in oxidative stress and toxicity.

Organismal life encounters reactive oxidants from internal metabolism and environmental toxicant exposure. Reactive oxygen and nitrogen species cause oxidative stress...

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Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway.

Inflammatory bowel diseases have been a risk factor of colorectal cancer (CRC). The reactive oxygen species (ROS) generated by inflammatory...

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