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AMPK Activation Promotes Tight Junction Assembly in Intestinal Epithelial Caco-2 Cells.

The AMP-activated protein kinase (AMPK) is principally known as a major regulator of cellular energy status, but it has been...

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Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players.

The physiologic stress induced by physical activity is reflected in immune system perturbations, oxidative stress, muscle injury, and inflammation. We...

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Immunoglobulin A as an anti-inflammatory agent

Immunoglobulin A (Ig)A is a class of antibodies that shows the highest daily synthesis, at a concentration of approximately 2–3 mg/ml,...

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Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.

Our intestine is colonized by an impressive community of commensals that has profound effects on the immune functions. The relationship...

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Nonalcoholic Fatty Liver Disease and Insulin Resistance: New Insights and Potential New Treatments.

Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders worldwide. It is associated with clinical...

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Astaxanthin Modulation of Signaling Pathways That Regulate Autophagy.

Autophagy is a lysosomal pathway that degrades and recycles unused or dysfunctional cell components as well as toxic cytosolic materials....

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Autophagy and aging: Maintaining the proteome through exercise and caloric restriction.

Accumulation of dysfunctional and damaged cellular proteins and organelles occurs during aging, resulting in a disruption of cellular homeostasis and...

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AMPK and autophagy get connected

Niida et al provide the first conclusive evidence that the DNA damage checkpoint kinases Chk1 and Chk2 are bona fide...

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Adaptogenic potential of curcumin in experimental chronic stress and chronic unpredictable stress-induced memory deficits and alterations in functional homeostasis.

The present study was designed to investigate the role of curcumin in chronic stress and chronic unpredictable stress-induced memory deficits...

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