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Protection of cerebellar granule cells by tocopherols and tocotrienols against methylmercury toxicity.

Excessive free radical formation has been implicated as one of the causative factors in neurotoxic damage associated with variety of...

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Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice.

We have recently shown that the tocotrienol-rich fraction (TRF) of palm oil, a mixture of vitamin E analogs, improves amyloid...

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Tocomin Restores Endothelium-Dependent Relaxation in the Diabetic Rat Aorta by Increasing NO Bioavailability and Improving the Expression of eNOS. Front Physiol.

We aimed to determine whether tocomin, an extract from palm oil that has a high tocotrienol content, was able to...

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Hypocholesterolemic activity of synthetic and natural tocotrienols.

Tocotrienols are farnesylated benzopyran natural products that exhibit hypocholesterolemic activity in vitro and in vivo. The mechanism of their hypolipidemic...

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The Role of Tocotrienol in Protecting Against Metabolic Diseases. Molecules.

Obesity is a major risk factor for diabetes, and these two metabolic conditions cause significant healthcare burden worldwide. Chronic inflammation...

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Comparing palm oil tocotrienol rich fraction with α-tocopherol supplementation on oxidative stress in healthy older adults.

Vitamin E is a fat-soluble compound and powerful antioxidant that have been shown to protect the cell membranes against damage...

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Vitamin E: Regulatory Role on Signal Transduction.

Vitamin E modulates signal transduction pathways by several molecular mechanisms. As a hydrophobic molecule located mainly in membranes it contributes...

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Vitamin E therapy beyond cancer: Tocopherol versus tocotrienol.

The discovery of vitamin E (α-tocopherol) began in 1922 as a vital component required in reproduction. Today, there are eight...

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Detrimental effects of 6 months exposure to very low doses of a mixture of six pesticides associated with chronic vitamin deficiency on rats.

This study aimed to evaluate the long-term low-dose effects of exposure to a mixture of 6 pesticide active substances (diquat,...

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