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The Role of Tocotrienol in Preventing Male Osteoporosis-A Review of Current Evidence.

Male osteoporosis is a significant but undetermined healthcare problem. Men suffer from a higher mortality rate post-fracture than women and...

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Tocotrienols Regulate Bone Loss through Suppression on Osteoclast Differentiation and Activity: A Systematic Review.

Background: There are accumulating studies reporting that vitamin E in general exhibits bone protective effects. This systematic review, however discusses...

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Regulatory role of vitamin E in the immune system and inflammation.

Vitamin E, a potent lipid-soluble antioxidant, found in higher concentration in immune cells compared to other cells in blood, is...

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Tocotrienols Modulate a Life or Death Decision in Cancers.

Malignancy often arises from sophisticated defects in the intricate molecular mechanisms of cells, rendering a complicated molecular ground to effectively...

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Tocotrienols: balancing the mitochondrial crosstalk between apoptosis and autophagy.

Tocotrienols are a group of natural vitamin E compounds with patent antitumoral effects, mostly based on their ability to induce...

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Tocotrienols induce apoptosis and autophagy in rat pancreatic stellate cells through the mitochondrial death pathway.

Background & aims: Selective removal of activated pancreatic stellate cells (PSCs) through induction of their own programmed death is a...

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Mitochondrial dysfunction in fibrotic diseases.

Although fibrosis is a common pathological feature of most end-stage organ diseases, its pathogenesis remains unclear. There is growing evidence...

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Alpha-Tocotrienol Prevents Oxidative Stress-Mediated Post-Translational Cleavage of Bcl-xL in Primary Hippocampal Neurons.

B-cell lymphoma-extra large (Bcl-xL) is an anti-apoptotic member of the Bcl2 family of proteins, which supports neurite outgrowth and neurotransmission...

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Safety and Neuroprotective Efficacy of Palm Oil and Tocotrienol-Rich Fraction from Palm Oil: A Systematic Review.

Background: Several natural products have been reported to elicit beneficial effects against neurodegenerative disorders due to their vitamin E contents....

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