Pericardial Fat and Coronary Artery Plaque

Purpose: To determine the relationship of pericardial fat, which secretes proinflammatory markers that have been implicated in coronary atherosclerosis, with atherosclerotic plaque in an asymptomatic population–based cohort.

Materials and Methods: In this institutional review board–approved study, all participants supplied written informed consent. One hundred eighty-three participants (89 women, 94 men; mean age, 61 years ± 9 [standard deviation]) from the community-based Multi-Ethnic Study of Atherosclerosis (MESA) were included. The coronary artery eccentricity (ratio of maximal to minimal coronary artery wall thickness) was determined by using magnetic resonance (MR) imaging and served as an index of plaque burden. The pericardial fat volume was determined by using computed tomography. Linear regression coefficient analysis was used to correlate pericardial fat volume with coronary artery wall thickness and plaque eccentricity.

Results: Pericardial fat volume correlated significantly with degree of plaque eccentricity (P < .05) in both men and women. After adjustments for body mass index (BMI) and waist circumference, traditional risk factors, C-reactive protein level, and coronary artery calcium content, the relationship between pericardial fat and plaque eccentricity remained significant in men (P < .01) but not in women. BMI and waist circumference correlated with degree of plaque eccentricity in the univariate model (P < .05) but not after adjustment for pericardial fat volume or traditional risk factors.

Conclusion: Pericardial fat volume, rather than BMI and waist circumference, was more strongly related to plaque eccentricity as a measure of coronary atherosclerotic plaque burden. The results support the proposed role of pericardial fat in association with atherosclerosis.

From press release:

Researchers have found more evidence supporting the role of fat around the heart in promoting atherosclerosis, according to a study published online in the journal Radiology.

New results from the Multi-Ethnic Study of Atherosclerosis (MESA) show that pericardial fat is more strongly related to coronary artery plaque than either body mass index (BMI) or waist circumference.

When plaque forms in the arteries, it deposits in an irregular manner, causing thickening of the artery wall on one side, but not the other. The ratio of the thick side to the thin side is referred to as plaque eccentricity and is a strong indicator of heart disease.

According to the American Heart Association, heart disease is the leading cause of death in the U.S. In 2010, an estimated 785,000 Americans had a new heart attack, and about 470,000 had a recurrent attack. Every 60 seconds, one person in the U.S. dies from a heart attack.

While previous studies have looked at the relationship of pericardial fat to atherosclerosis in patients with severe coronary disease, this is the first study to determine the association of pericardial fat on coronary artery plaque burden in asymptomatic individuals.

"The individuals in this study had no symptoms and were otherwise healthy," said senior author David A. Bluemke, M.D., Ph.D., director of Radiology and Imaging Sciences at the National Institutes of Health (NIH) Clinical Care. "They did not have significant coronary artery narrowing. Yet, despite this, they had coronary plaque that could be detected by MRI."

For the study, 183 individuals without clinical cardiovascular disease were recruited from the Baltimore and Chicago field centers of MESA, a study funded by the NIH. Participants included 89 women and 94 men with a mean age of 61 years.

"The individuals were fairly representative of the U.S. population, although the majority were overweight," Dr. Bluemke said.

The researchers used magnetic resonance imaging (MRI) to measure coronary artery eccentricity (ratio of maximal to minimal artery wall thickness) as a measure of early-stage atherosclerosis and computed tomography (CT) to determine pericardial fat volume.

"Pericardial fat is located behind the sternum, around the heart, and we cannot see it except with CT or MRI," Dr. Bluemke said. "In some people, extra fat forms preferentially in this area. We do not know why. However, extra fat around the heart is generally associated with being overweight or obese."

The results showed that pericardial fat volume correlated significantly with the degree of plaque eccentricity in both men and women. After adjustment for BMI, waist circumference, traditional risk factors, C-reactive protein level and coronary calcium content, the relationship between pericardial fat and plaque eccentricity remained significant in men, but not in women.

"The findings indicate yet another reason that obesity is bad for us," Dr. Bluemke said. "It is particularly bad when the fat forms around the heart, since the heart fat appears to further promote coronary artery plaque."