HEALTH NEWS

Study Title:

Vitamin K and bone.

Study Abstract

Vitamin K is mainly known as an agent involved in blood coagulation, maintaining the activity of coagulation factors in the liver. In addition, epidemiological studies suggested that a lack of vitamin K is associated with several diseases, including osteoporosis and vascular calcification. There are two main kinds of vitamin K: Phylloquinone (or PK) and Menaquinones (MKn), both act as co-enzyme of y-glutamyl carboxylase (GGCX) transforming under-carboxylated in carboxylated vitamin K dependent proteins, such as Bone Gla Protein (or Osteocalcin) and Matrix Gla Protein. Recently, Vitamin K was also identified as a ligand of the nuclear steroid and xenobiotic receptor (SXR) (in murine species Pregnane X Receptor: PXR), expressed in osteoblasts. The purpose of this literature review is to evaluate the protective role of Vitamin K in bone and vascular health.

Study Information

Clin Cases Miner Bone Metab. 2017 May-Aug;14(2):200-206. doi: 10.11138/ccmbm/2017.14.1.200. Epub 2017 Oct 25. PMID: 29263734; PMCID: PMC5726210.

Full Study

https://pubmed.ncbi.nlm.nih.gov/29263734/