The fine structure of chondrocytes

The structure of articular cartilage under the electron microscope has been studied in the rabbit. These observations have been confirmed and extended in the mouse (Silberberg,
Silberberg & Feir, 1964). All these studies were made on tissue fixed with osmium tetroxide; this fixative gives good preservation of the fine structure of the cell, but has the disadvantage
that it inactivates all the cell enzymes. A number of aldehyde fixatives have been introduced to overcome this drawback (Sabatini, Bensch & Barrnett, 1962, 1963), and of these the most promising appears to be glutaraldehyde.