HEALTH NEWS
Study Title:
Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis.
Study Abstract
We tested whether inhibiting mechanically responsive articular chondrocyte mitochondria after severe traumatic injury and preventing oxidative damage represent a viable paradigm for posttraumatic osteoarthritis (PTOA) prevention. We used a porcine hock intra-articular fracture (IAF) model well suited to human-like surgical techniques and with excellent anatomic similarities to human ankles. After IAF, amobarbital or N-acetylcysteine (NAC) was injected to inhibit chondrocyte electron transport or downstream oxidative stress, respectively. Effects were confirmed via spectrophotometric enzyme assays or glutathione/glutathione disulfide assays and immunohistochemical measures of oxidative stress. Amobarbital or NAC delivered after IAF provided substantial protection against PTOA at 6 months, including maintenance of proteoglycan content, decreased histological disease scores, and normalized chondrocyte metabolic function. These data support the therapeutic potential of targeting chondrocyte metabolism after injury and suggest a strong role for mitochondria in mediating PTOA.
Study Information
Sci Transl Med. 2018 Feb 7;10(427):eaan5372. doi: 10.1126/scitranslmed.aan5372. PMID: 29437147; PMCID: PMC5987523Full Study
https://pubmed.ncbi.nlm.nih.gov/29437147/Recent News
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