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Study Title:

Selectivity of Ca2+ channel blockers for dilator actions on the isolated lower esophageal sphincter and aorta from rats.

Study Abstract

We compared dilator actions of representative four Ca2+ channel blockers on the isolated lower esophagus sphincter (LES) and thoracic aorta from rats. Verapamil, diltiazem, nifedipine and cilnidipine suppressed KCl-induced contractions of LES and thoracic aorta in a concentration-dependent manner. The order of selectivity for LES, which was calculated as ratio of IC50 value for thoracic aorta divided by that for LES, was diltiazem > verapamil > nifedipine > cilnidipine. These results suggest that diltiazem more preferentially dilates the LES whereas cilnidipine is expected to have lower potential risk of gastroesophageal dysfunction during the antihypertensive therapy.

KEYWORDS:
Ca(2+) channel blockers; Lower esophagus sphincter; Thoracic aorta

Study Information

J Pharmacol Sci. 2018 May;137(1):98-100. doi: 10.1016/j.jphs.2018.01.012. Epub 2018 Apr 19.

Full Study

https://www.ncbi.nlm.nih.gov/pubmed/29709270