HEALTH NEWS

Study Title:

Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease

Study Abstract

Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that plays a central role in limiting host immune response to pathogens, thereby preventing damage to the host and maintaining normal tissue homeostasis. Dysregulation of IL-10 is associated with enhanced immunopathology in response to infection as well as increased risk for development of many autoimmune diseases. Thus a fundamental understanding of IL-10 gene expression is critical for our comprehension of disease progression and resolution of host inflammatory response. In this review, we discuss modes of regulation of IL-10 gene expression in immune effector cell types, including signal transduction, epigenetics, promoter architecture, and post-transcriptional regulation, and how aberrant regulation contributes to immunopathology and disease progression.

Study Information

Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease
Crit Rev Immunol.
2015 January

Full Study

http://www.ncbi.nlm.nih.gov/pubmed/22428854