HEALTH NEWS

Study Title:

Oxytocin Modulates Appetite

Study Abstract

Oxytocin (OT) effect on ghrelin-stimulated neuropeptide Y (NPY) secretion was evaluated in 12 normal men. Tests: ghrelin (1 mug/kg B.W. as an intravenous bolus), OT (2 mIU/min infusion), ghrelin plus OT; normal saline. Plasma NPY did not change during saline or OT infusions, whereas it showed a significant 29% increase vs baseline at 15 min after ghrelin injection. When OT was present, ghrelin-induced NPY increment was completely abolished. Results show that oxytocin modulates the NPY response to ghrelin, whereas it is unable to produce direct inhibitions of basal circulating NPY levels.

Study Information

Oxytocin inhibits the stimulatory effect of ghrelin on circulating neuropeptide Y levels in humans.Coiro V, Saccani-Jotti G, Rubino P, Manfredi G, Vacca P, Volta E, Chiodera P.
Oxytocin inhibits the stimulatory effect of ghrelin on circulating neuropeptide Y levels in humans.
J Neural Transm.
2008 May
Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci, 14-43100, Parma, Italy.