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Study Title:

Oxidative stress, antioxidants, and lipid profile in the serum and saliva of individuals with coronary heart disease: is there a link with periodontal health?

Study Abstract

BACKGROUND:
Oxidative stresses and dyslipidemia are an important risk factor in the development of coronary atherosclerotic complications like angina pectoris and myocardial infarction. The aim of this study was to find the relationship between the salivary lipid profile, lipid peroxidation and antioxidants and the periodontal health status of patients with acute coronary heart disease.

METHODS:
Forty s who had experienced a recent attack of angina pectoris or myocardial infarction and another 40 noncardiac patients matched for age, sex and residence (control) were recruited. The lipid profile level, lipid peroxidation and antioxidant status were measured in the serum and saliva of all participants together with lactate dehydrogenase (LDH) and C-reactive protein (CRP). The studied parameters were then correlated with the periodontal status of the participant using the clinical periodontal sum score (CPSS). A multiple linear regression was used to assess the net effect of each set of independent variables on the outcome variable using SPSS-21. A P value ≤ 0.05 was considered statistically significant.

RESULTS:
Salivary total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C), Malondialdehyde (MDA), uric acid (UA), superoxide dismutase (SOD) and lactate dehydrogenase (LDH) levels increased with the upper tertile of the CPSS, while salivary high-density lipoprotein-cholesterol (HDL-C) decreased with the upper tertile of the CPSS.

CONCLUSION:
Periodontal health status could be considered as an independent risk factor for acute coronary heart disease (CHD).

Study Information

Minerva Stomatol. 2017 Jul 12. doi: 10.23736/S0026-4970.17.04062-6. [Epub ahead of print]

Full Study

https://www.ncbi.nlm.nih.gov/pubmed/28707864