HEALTH NEWS

Study Title:

Mitochondrial dysfunction is involved in the aggravation of periodontitis by diabetes.

Study Abstract

AIM:
To elucidate whether mitochondrial dysfunction contributes to aggravated periodontitis in diabetes.

MATERIALS AND METHODS:
Sixty-four wistar rats were randomly assigned into four groups: control, periodontitis, diabetes, and diabetic periodontitis. Two weeks after induction of diabetes, periodontitis was induced by silk ligation for 2 weeks and thereafter evaluated by assessing alveolar bone loss and apoptosis of periodontium cells. Mitochondrial oxidative stress was detected by MitoSOX staining. Mitochondrial function was determined by measuring ATP production, and by assessing mitochondrial DNA copy number, activities of electron transport chain complexes, and biogenesis with real-time PCR.

RESULTS:
Significantly severer bone loss, enhanced periodontium cell apoptosis, and mitochondrial oxidative stress were found in the rats with diabetic periodontitis than the others. Furthermore, diabetic rats with periodontitis presented severer mitochondrial dysfunction than lean rats with periodontitis, as reflected by compromised ATP production, decreased mitochondrial DNA copy number, reduced gene expression of electron transport chain complex I subunits, and impaired mitochondrial biogenesis (p < 0.05). Multiple regression analysis further indicated a close correlation between these mitochondrial events and bone loss in diabetic periodontitis.

CONCLUSIONS:
Mitochondrial dysfunction was positive correlated to aggravated periodontitis in diabetes and might represent a therapeutic target for diabetic periodontitis.

© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

KEYWORDS:
diabetes; mitochondrial biogenesis; mitochondrial dysfunction; oxidative stress; periodontal disease(s)

Study Information

J Clin Periodontol. 2017 May;44(5):463-471. doi: 10.1111/jcpe.12711. Epub 2017 Apr 12.

Full Study

https://www.ncbi.nlm.nih.gov/pubmed/28207937