HEALTH NEWS

Study Title:

Increased salivary oxidative stress parameters in patients with type 2 diabetes: Relation with periodontal disease.

Study Abstract

OBJECTIVE:
The aim of this study was to determine whether there are differences in salivary oxidative stress between patients with diabetes mellitus type 2 (DM2) and healthy non-diabetic patients, and whether this oxidative stress is associated with the presence of periodontal disease in diabetic patients.

MATERIAL AND METHODS:
This observational study included 70 patients divided into three groups according to metabolic control levels: 19 non-diabetic patients (control group); 24 patients with good metabolic control (HbA1c<7%), and 27 patients DM2 with poor metabolic control (HbA1c>7%). The following oxidative stress parameters were measured in all subjects: glutathione peroxidase (GPx), glutathione reductase (GRd), reduced glutathione (GSH) and oxidized glutathione (GSSG). Periodontal health was determined by means of the community periodontal index (CPI) recommended by the WHO.

RESULTS:
The diabetic group with good metabolic control showed a significant increase in GPx and GRd activity in comparison with the control group (P<.001). The activity of the enzymes measured was significantly less in patients with poor metabolic control in comparison with the control group and well-controlled diabetic groups (P<.001). Both diabetic groups showed higher GSSG/GSH quotients and CPI in comparison with the control group, and both parameters were significantly higher in diabetic patients with poor metabolic control in comparison with well-controlled diabetic patients.

CONCLUSIONS:
Poor metabolic control in DM2 patients is associated with higher levels of salivary oxidative stress and worse periodontal health.

Copyright © 2017 SEEN. Publicado por Elsevier España, S.L.U. All rights reserved.

KEYWORDS:
Diabetes mellitus; Enfermedad periodontal; Estrés oxidativo; Oxidative stress; Periodontal disease; Saliva

Study Information

Endocrinol Diabetes Nutr. 2017 May;64(5):258-264. doi: 10.1016/j.endinu.2017.03.005. Epub 2017 Apr 26.

Full Study

https://www.ncbi.nlm.nih.gov/pubmed/28495321