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Study Title:

Food intolerance and chronic constipation: manometry and histology study.

Study Abstract

BACKGROUND:
Chronic constipation in children can be caused by cows' milk intolerance (CMI), but its pathogenesis is unknown.
AIMS:
To evaluate the histology and manometry pattern in patients with food intolerance-related constipation.
PATIENTS AND METHODS:
Thirty-six consecutive children with chronic constipation were enrolled. All underwent an elimination diet and successive double-blind food challenge. All underwent rectal biopsy and anorectal manometry.
RESULTS:
A total of 14 patients were found to be suffering from CMI and three from multiple food intolerance. They had a normal stool frequency on elimination diet, whereas constipation recurred on food challenge. The patients with food intolerance showed a significantly higher frequency of erosions of the mucosa, and the number of intra-epithelial lymphocytes and eosinophils. The rectal mucous gel layer showed that the food-intolerant patients had a significantly lower thickness of mucus than the other subjects studied. Manometry showed a higher anal sphincter resting pressure and a lower critical volume in food intolerance patients than in the others suffering from constipation unrelated to food intolerance. Both histology and manometry abnormalities disappeared on the elimination diet.
CONCLUSIONS:
Food intolerance-related constipation is characterized by proctitis. Increased anal resting pressure and a reduced mucous gel layer can be considered to be contributory factors in the pathogenesis of constipation.

Study Information

Food intolerance and chronic constipation: manometry and histology study.
Eur J Gastroenterol Hepatol.
2006 February

Full Study

http://www.ncbi.nlm.nih.gov/pubmed/16394795