HEALTH NEWS

Study Title:

Effects of Oral Supplementation with Pyrroloquinoline Quinoneon Stress, Fatigue, and Sleep

Study Abstract

Seventeen adult male and female subjects participated in a clinical trial using an open-label
trial to evaluate the effectiveness of pyrroloquinoline quinone (PQQ) on stress, fatigue, quality
of life and sleep. They ingested 20 mg of PQQ daily for 8 weeks. Changes in stress, fatigue,
quality of life measures and sleep were evaluated using various inventories and
questionnaires. For example, the results of the Profile of Mood States-Short Form revealed that
all six measures of vigor, fatigue, tension-anxiety, depression, anger-hostility and confusion
were significantly improved following PQQ administration compared with scores for those
measures before administration of PQQ. Measures for quality of life, appetite, sleep,
obsession and pain, also improved significantly. The results of the Oguri-Shirakawa-Azumi
Sleep Inventory (Middle Aged and Aged version) showed significant improvement in
sleepiness at awakening, sleep onset and maintenance, and sleep duration. For validation, the
Pittsburgh Sleep Quality Index Japanese version also showed significant improvement in
sleep-related behavior. Furthermore, the changes in these global scores were correlated with
Functional Foods in Health and Disease 2012, 2(8):307-324 Page 308 of 324
changes in the cortisol awakening response (R = -0.55), i.e. the effects of PQQ on
improvement of sleep quality are supported by a biomarker

Study Information

Masahiko Nakano, Tetsuro Yamamoto,Hisayoshi Okamura, Akira Tsuda, and Yasuyuki Kowatari
Effects of Oral Supplementation with Pyrroloquinoline Quinoneon Stress, Fatigue, and Sleep

2012 January