HEALTH NEWS

Study Title:

Anticholinergic effects of common drugs are associated with increased mortality in over 65s

Study Abstract

The combined anticholinergic effects of many common drugs increase the risk of cognitive impairment and death in people aged over 65, a large scale study of the long term effect of drugs on health has found.

Taking just two drugs with anticholinergic effects, such as some drugs for heart disease, antihistamines, antidepressants, antipsychotics, and even warfarin, can treble the risk of death in the over 65s. Doctors have been advised to assess the combined anticholinergic burden of all drugs that a patient is taking—prescribed drugs and those bought over the counter—before prescribing any additional ones. GPs have also been reminded of the importance of regularly reviewing patients’ drugs.

Study Information

Anticholinergic effects of common drugs are associated with increased mortality in over 65s
BMJ
2011 June

Full Study

http://www.bmj.com/content/342/bmj.d4037.long