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Study Title:

Acquired flucytosine resistance during combination of caspofungin and flucytosine for Candida glabra

Study Abstract

Treatment of Candida glabrata cystitis remains a therapeutic challenge and antifungal combination using flucytosine is one option. We describe 2 patients with refractory C. glabrata cystitis who failed flucytosine combined with caspofungin with early-acquired high-level resistance to flucytosine due to nonsense mutations in the FUR1 gene. Rapid acquired flucytosine resistance with microbiological failure should discourage combination of caspofungin and flucytosine during urinary candidiasis.

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Study Information

Acquired flucytosine resistance during combination of caspofungin and flucytosine for Candida glabrata cystitis
Antimicrob Agents Chemother.
2015 November