HEALTH NEWS

PEA Ultra: A Revolutionary Nutrient for Health and Repair

By Dr. Linda J. Dobberstein, DC, Board Certified in Clinical Nutrition

July 15, 2024

PEA Ultra: A Revolutionary Nutrient for Health and Repair

Article highlights:

•  PEA significantly enhances your body’s resilience and recovery, supporting immune vitality, brain health, visual health, joint comfort, mast cell function, and more.

•  PEA has a calming effect on nerves, helping minor pain, sleep, and focus.

•  PEA levels decline with age, stress, and illness, making supplementation pivotal for maintaining health and vitality.

•  Wellness Resources PEA Ultra is a bioavailable, ultra-micronized PEA for maximum health benefits.


Have you checked out PEA Ultra? It is not the green or yellow peas you may have in your kitchen. Rather, PEA (palmitoylethanolamide) is a specialized lipid highly acclaimed in research and health circles. PEA is one of my favorite nutrients, and it might become yours too! Discover its remarkable benefits and how it can revolutionize your approach to health, recovery, and repair!

What Is PEA?

PEA (palmitoylethanolamide) has intrigued researchers since the 1950’s due to its vast health benefits. PEA is a special type of lipid or fat that your brain and other body tissues naturally make, but with age, stress, illness, etc., levels decline. Small amounts of PEA are found in egg yolk, peanuts, soybeans, roasted coffee, black-eyed peas, apples, and potatoes.

Restores Homeostasis Throughout Your Body

PEA is commonly used for brain and nervous system health. It is also utilized throughout your immune system, respiratory tract, gastrointestinal tract, vascular system, joints, adrenal glands, spleen, kidneys, liver, heart, brain, testes, diaphragm, skin, mouth, eyes, and placenta.

PEA works in cells to restore homeostasis, or balance. It is a powerful, masterful modulatory agent for your immune system making it vital for anyone who wants to calm or support their immune system function. PEA also works as an anti-aging, immune-enhancing, nootropic, and gut microbiome modulating agent.

PEA works by directly influencing inflammatory cascades and targets numerous compounds like PPAR-alpha, CB1, CB2, TNF-alpha, NF-kappa B, MMPs, and several others. CB1 and -2 are cannabinoid receptors. It neutralizes these chemicals that cause inflammation, chronic irritation, over-activation, and destruction while producing a calming, comforting, stabilizing effect and homeostasis.

Protector of Brain-Immune-Gut System

One of PEAs most impressive benefits is its modulatory effects with immune system activities in the brain and gastrointestinal tract. PEA is involved with regulation of macrophages, cytokines, and mast cells that produce inflammatory compounds. PEA acts as a calming agent in your immune system reducing sensitivities and histamine release as it stabilizes mast cell activity.

PEA enhances your immune system’s ability to resist bacteria and viruses. It modulates macrophages and glial cells, the housekeeping cells, in your brain and nervous system to keep them efficient for their duties but not overworked and irritated. 

PEA is also involved with the maintenance of your gut-barrier and microbiome health. It helps stimulate the regeneration of colon cells and increases signaling of calming compounds within the gastrointestinal tract.

Stabilizes Mast Cell Activity

PEA inhibits mast cells from releasing histamine, TNF-alpha, and many other compounds. Mast cells are found in your brain, gastrointestinal tract, lungs and respiratory tract, cartilage and joints, bones, cardiovascular system, skin and other tissues.

Excess release of histamine by mast cells can lead to itching, flushing, increased gastric acid and other gastrointestinal symptoms, nasal and airway congestion, fatigue, confusion, stress-induced headaches, dysregulation of the sleep-wake cycle, vascular system and blood pressure, and other symptoms.

Foods rich in histamine or an intolerance to certain foods, chemicals, stress, germs, insect bites, exercise, medications, mold toxicity, etc. can trigger excess histamine release in your body.

Lungs and Respiratory Tract

PEA decreases the activation of mast cells within the lungs, reduces neutrophil levels, a type of white blood cell, and modulates cytokine levels in respiratory tract. It provides substantial benefits against oxidative stress to respiratory tissues. It helps protect airway passages from irritation and calms sensitivities.

Blood Vessel Support

PEA is used by blood vessels in protection against oxidative stress. It provides protection against infiltration of ROS free radicals and cytokine production (IL-1 beta IL-6, and TNF-a) that lead to changes in the blood vessel structure. PEA helps keep blood vessels structurally healthy protecting against oxidative stress.

Skin Health

PEA supports skin hydration, quality, and barrier integrity. This allows the skin to retain moisture and decrease skin sensitivity. PEA may be used with other skin supporting nutrients like Hyaluronic Acid, Green Tea Extract, and Collagen Peptides, to keep that healthy glow.

Eye Health

In Europe, PEA is commonly used to help support eye health with the retina and intraocular pressure. A recent clinical trial demonstrated that taking 600 mg of PEA daily for four months was shown to enhance aqueous fluid flow within the eye and increase electrical activity of the retina. Other findings include increased blood flow and a neuroprotective effect within the eye.

Joints and Cartilage

PEA modulates the production and expression of damaging compounds like TNF-a, 5-Lox, MMPs, and others within cartilage and joints. Studies demonstrate its effectiveness at reducing mast cell activity and several cytokine levels in joints, thus improving comfort, mobility, and activity levels.

Brain Protection

PEA for brain health and protection is exceptional. Your brain naturally produces PEA, but life challenges, stress, and aging oftentimes necessitate extra support. PEA helps improve mental sharpness, mood, and sleep repair. 

PEA reduces the release and expression of compounds such as TNF-alpha, prostaglandin E2, NF-kappaB, and inhibits microglial cell overactivity and stress responses in your brain and nerves. It inhibits excess calcium release in cells and reduces lipid peroxidation that may cause further stress to nerves and microglial cells.

Furthermore, PEA stabilizes mast cell release of histamine in the brain that can result in stress headaches. It also supports blood brain barrier (BBB) integrity, which has some similarities to gut lining integrity. Studies show PEA provides highly valuable neuroprotective effects for mood, mental and cognitive health, balance and movement support, and more.

Dosage

Wellness Resources PEA Ultra contains ultra-micronized Levagen®+ PEA with superior absorption and bioavailability. Common dosages used in research range from 600-1800 mg/day for 4-6 months or longer. It may be taken with or without food during the day or at bedtime.

PEA Ultra may be used with other nutrients like Acetyl-l-Carnitine, Fisetin, R-Alpha-Lipoic Acid, Astaxanthin, Turmeric Gold, Quercetin, and/or Glutathione Ultra, to create synergistic effects.

PEA has a profound impact on your body’s resiliency and recovery. This specialized lipid is used ubiquitously for tissues and organs ranging from immune recognition and vitality, visual health, vascular and gastrointestinal integrity, brain health, joint comfort and management of inflammatory mechanisms, mast cell and microglial cell management, cell signaling, and more. Impressive! It is a favorite of mine and our customers too. PEA Ultra is an essential supplement for staying well!

Additional PEA articles:

PEA: Natural Support for Nerves and Comfort

PEA Calms Digestive Stress and Improves Bowel Motility

PEA for Healthy Mast Cell Activity

PEA Effective for Exercise Recovery and Athletes

Research article: Therapeutic Use of Palmitoylethanolamide as an Anti-Inflammatory and Immunomodulator

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