Substance P is a neuropeptide that is typically ”over-heated” in situations of mood, sleep, nerve, and cardiovascular deterioration. New research shows that one of the first signs of magnesium deficiency¹ is that it enables the over-production of substance P.

Because magnesium affects several hundred enzyme systems in your body involved with energy production, nerve function, muscle function, digestive function, cardiovascular function, etc. it is somewhat difficult to know specific symptoms indicating deficiency. On the other hand, you can assume deficiency is associated with almost any metabolic problem you are having especially if stress is an aggravating factor (you are stress sensitive, you are easily tired out by stress, and/or you don’t sleep well). I associate easy irritation, agitation, and/or a short fuse with a lack of magnesium.

This new study indicates that a lack of magnesium sets the stage for the inability of your body to handle high stress or trauma – resulting in perpetual inflammatory cascades that are the hallmark of worsened health.

This study says that low magnesium enables excessive substance P response. In other words, if you are cruising through life with a lack of magnesium – sort of stressed, sort of irritable, and then something traumatic happens (emotional or physical) or you simply have a period of high stress for an extended period of time, then you will be susceptible to these high demands pushing you body into a condition of substance P overload.

This information is relevant to everyone. First of all, make sure you have adequate magnesium in your supplements, 400 mg – 800 mg a day – higher levels if you are under higher stress in general and/or if you exercise a lot (magnesium is lost in sweat). If a high level stress event happens to you, ensure you maximize magnesium intake during the duration of the event and until you feel fully recovered. This simple strategy could save you years of misery.

Once a substance P problem exists this new study supports the use of magnesium to help clear it up. For many years I have used calcium AEP, quercetin, and acetyl-l-carnitine to help resolve this issue. It appears that adequate magnesium is also an important part of this strategy.