Too much Substance P in your nerves will also interfere with sleep, making you feel wired or anxious, similar to how a Hypocretin problem feels (explained in the previous section). However, Substance P is not involved with pleasure urges or reward behavior. It is part of a natural system that processes pain and inflammation.

Hypocretin problems are associated with your hypothalamus gland (subconscious control center) whereas Substance P problems are associated with your brain stem and nerve endings all around your body. Many people have features of both problems and need to address both issues; others mostly just have one of these ...