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An overview of a novel, water-soluble undenatured type II collagen (NEXT-II).

BACKGROUND:Osteoarthritis, the most common form of arthritis, is a crippling, chronic debilitating bone disease that commonly affects humans, dogs, and...

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Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study.

BACKGROUND:Undenatured type II collagen (UC-II) is a nutritional supplement derived from chicken sternum cartilage. The purpose of this study was...

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The role of interleukin-8 in inflammation and mechanisms of regulation.

Interleukin-8 (IL-8) is a chemoattractant cytokine produced by a variety of tissue and blood cells. Unlike many other cytokines, it...

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Evaluation of the anti-inflammatory actions of various functional food materials including glucosamine on synovial cells.

The anti-inflammatory actions of glucosamine (GlcN) on arthritic disorders involve the suppression of inflammatory mediator production from synovial cells. GlcN...

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Oral administration of undenatured native chicken type II collagen (UC-II) diminished deterioration of articular cartilage in a rat model of osteoarthritis (OA).

OBJECTIVE:The aim of this study was to determine the ability of undenatured native chicken type II collagen (UC-II) to prevent...

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Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen.

Although oral administration of protein antigens may lead to specific immunologic unresponsiveness, this method of immunoregulation has not been applied...

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Oral administration of type-II collagen peptide 250-270 suppresses specific cellular and humoral immune response in collagen-induced arthritis.

Oral antigen is an attractive approach for the treatment of autoimmune and inflammatory diseases. Establishment of immune markers and methods...

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Cytotoxic T lymphocytes recognize and lyse chondrocytes under inflammatory, but not non-inflammatory conditions.

The human major histocompatibility complex (MHC) class I allele HLA-B27 is strongly associated with seronegative spondyloarthropathies including ankylosing spondylitis and...

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Oligosaccharides: a boon from nature's desk.

This article reviews the varied sources of oligosaccharides available in nature as silent health promoting, integral ingredients of plants as...

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