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Targeting Natural Killer Cells for Improved Immunity and Control of the Adaptive Immune Response

Natural killer (NK) cells are critical for targeting and killing tumor, virus-infected and stressed cells as a member of the...

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Vitamin d deficiency reduces the immune response, phagocytosis rate, and intracellular killing rate of microglial cells

Meningitis and meningoencephalitis caused by Escherichia coli are associated with high rates of mortality and neurological sequelae. A high prevalence...

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Vitamin D supplementation during pregnancy and infancy reduces aeroallergen sensitization: a randomized controlled trial

Background: Vitamin D has immune-modulating effects. We determined whether vitamin D supplementation during pregnancy and infancy prevents aeroallergen sensitization and...

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Key Vitamin D Target Genes with Functions in the Immune System

The biologically active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), modulates innate and adaptive immunity via genes regulated by the...

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Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response

In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but...

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Mechanisms of Action of Vitamin D as Supplemental Therapy for Pneumocystis Pneumonia

The combination of trimethoprim and sulfamethoxazole (TMP-SMX) is the most effective regimen for therapy of Pneumocystis pneumonia (PCP). As many...

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Role of vitamin D in preventing of COVID-19 infection, progression and severity

The outbreak of COVID-19 has created a global public health crisis. Little is known about the protective factors of this...

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Primary Vitamin D Target Genes of Human Monocytes

The molecular basis of vitamin D signaling implies that the metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) of the secosteroid vitamin D3 activates...

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Vitamin D Toxicity

Vitamin D is a fat-soluble vitamin that is found in some animal food products and is also synthesized in our...

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