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Physiological and Pathological Role of Circadian Hormones in Osteoarthritis: Dose-Dependent or Time-Dependent?

Osteoarthritis (OA), the most common form of arthritis, may be triggered by improper secretion of circadian clock-regulated hormones, such as...

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Circadian Rhythms and Mitochondria: Connecting the Dots.

Circadian rhythms provide a selective advantage by anticipating organismal nutrient needs and guaranteeing optimal metabolic capacity during active hours. Impairment...

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The brain-joint axis in osteoarthritis: nerves, circadian clocks and beyond.

Osteoarthritis (OA) is a prevalent and debilitating joint disease for which ageing, obesity and chronic inflammation are known risk factors....

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Life time-circadian clocks, mitochondria and metabolism.

A functional circadian clock has long been considered a selective advantage. Accumulating evidence shows that the clock coordinates a variety...

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Potential predictors of hippocampal atrophy in Alzheimer's disease.

The hippocampus is a vulnerable and plastic brain structure that is damaged by a variety of stimuli, e.g. hypoxia, hypoperfusion,...

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Osteoarthritis Was Associated With a Faster Decline in Hippocampal Volumes in Cognitively Normal Older People.

Objective: To examine whether osteoarthritis (OA) is associated with a change in adjusted hippocampal volumes (HpVR: hippocampal/intracranial volume × 103)...

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Osteoarthritis increases the risk of dementia: a nationwide cohort study in Taiwan.

Osteoarthritis (OA) and dementia are prevalent causes of disability in geriatric patients. To date, information on the temporal correlation between...

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The Role of Chronic Inflammatory Bone and Joint Disorders in the Pathogenesis and Progression of Alzheimer's Disease.

Late-onset Alzheimer's Disease (LOAD) is a devastating neurodegenerative disorder that causes significant cognitive debilitation in tens of millions of patients...

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Mitophagy in Alzheimer's Disease and Other Age-Related Neurodegenerative Diseases.

Mitochondrial dysfunction is a central aspect of aging and neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and...

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