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Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration.

Oxidative stress-induced mitochondrial dysfunction and nucleus pulposus (NP) cell apoptosis play crucial roles in the development of intervertebral disc degeneration...

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Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality.

Arthritis causes disability due to pain and inflammation in joints. There are many forms of arthritis, one of which is...

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Hyaluronan suppresses lidocaine-induced apoptosis of human chondrocytes in vitro by inhibiting the p53-dependent mitochondrial apoptotic pathway.

Aim: Intra-articular injection of local anesthetics (LAs) is a common procedure for therapeutic purposes. However, LAs have been found toxic...

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Mitochondria in Injury, Inflammation and Disease of Articular Skeletal Joints.

Inflammation is an important biological response to tissue damage caused by injury, with a crucial role in initiating and controlling...

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The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis.

Knee osteoarthritis (KOA) is a chronic multifactorial pathology and a current and essential challenge for public health, with a negative...

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Effect of chondrocyte mitochondrial dysfunction on cartilage degeneration: A possible pathway for osteoarthritis pathology at the subcellular level.

Previous studies identified that chondrocyte apoptosis serves an important role in osteoarthritis (OA). However, the mechanisms of cartilage degeneration induced...

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Mitochondrial dysfunction induces muscle atrophy during prolonged inactivity: A review of the causes and effects.

Prolonged skeletal muscle inactivity (e.g. limb immobilization, bed rest, mechanical ventilation, spinal cord injury, etc.) results in muscle atrophy that...

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Mitophagy in degenerative joint diseases.

Mitochondrial dysfunction is involved in aging and multiple degenerative diseases, including intervertebral disc degeneration (IVDD) and osteoarthritis (OA). Thus, the...

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Role of Mitochondria in Physiology of Chondrocytes and Diseases of Osteoarthritis and Rheumatoid Arthritis.

Purpose of review: Mitochondria are recognized to be one of the most important organelles in chondrocytes for their role in...

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