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The Importance of Brain Insulin Signaling

The unparalleled global rates of obesity and type 2 diabetes, together with the associated cardiovascular morbidity and mortality, are referred...

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Diabetic Medications are Not Equipped to Handle the Complexity of the Problem

The central nervous system is essential in maintaining energy and glucose homeostasis. In both animals and humans, efficient cerebral insulin...

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How Problems in White Adipose Tissue Cause Diabetes

The classical perception of adipose tissue as a storage place of fatty acids has been replaced over the last years...

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Adiponectin Prevents Muscle-Related Insulin Resistance

The adipocyte hormone adiponectin is negatively correlated with obesity and insulin resistance and may exert an important antidiabetes function. In...

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Inflamed Fat Impairs Insulin Signaling

CONTEXT: Adipose tissue is increasingly recognized as an active endocrine organ with many secretory products and part of the innate...

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White Adipose Tissue and Insulin Resistance

White adipose tissue was believed to be just an energy-storage organ, but it is now recognized to be an active...

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Type II Diabetes and Autoimmune Complications

Diseases gain identity from clinical phenotype as well as genetic and environmental aetiology. The definition of type 1 diabetes is...

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Mixed Type I and Type II Diabetes

Type 1 and type 2 diabetes frequently co-occur in the same families, suggesting common genetic susceptibility. Such mixed family history...

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Carnosine Reduces the Glycation of LDL Cholesterol

Glycation of low-density lipoprotein (LDL) by reactive aldehydes, such as glycolaldehyde, can result in the cellular accumulation of cholesterol in...

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