Ubiquinol Q10 Supplementation Activates Mitochondria Functions to Offset Aging

Aim: The present study was conducted to define the relationship between the anti-aging effect of ubiquinol-10 supplementation and mitochondrial activation in SAMP1 mice.

Results: Here, we report that dietary supplementation with ubiquinol-10 prevents age-related decreases in the expression of sirtuin gene family members that results in the activation of PGC-1α, a major factor that controls mitochondrial biogenesis and respiration, as well as SOD2 and IDH2, which are major mitochondrial antioxidant enzymes. Ubiquinol-10 supplementation can also increase mitochondrial complex I activity and decrease levels of oxidative stress markers, including protein carbonyls, AP sites, malondialdehydes, and the GSH/GSSG ratio. Furthermore, ubiquinol-10 may activate Sirt1 and PGC-1α by increasing cAMP levels that in turn activate CREB and AMPK.

Innovation and Conclusion: These results show that ubiquinol-10 may enhance mitochondrial activity by increasing levels of Sirt1, PGC-1α and Sirt3 that slow the rate of age-related hearing loss and protect against the progression of aging and symptoms of age-related diseases.