This proposed regulatory amendment would adopt a No Significant Risk Level (NSRL) for glyphosate under Proposition 651 in Title 27, California Code of Regulations, section 25705(b)2. The proposed NSRL of 1100 micrograms per day (µg/day) is based on a carcinogenicity study in rodents and was derived using the methods described in Section 25703.
Proposition 65 was enacted as a ballot initiative on November 4, 1986. The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is the lead state entity responsible for the implementation of Proposition 653. OEHHA has the authority to adopt and amend regulations to implement and further the purposes of the Act4.
The Act requires businesses to provide a warning when they cause an exposure to a chemical listed as known to the state to cause cancer or reproductive toxicity. The Act also prohibits the discharge of listed chemicals to sources of drinking water. When exposures are insignificant, warnings are not required and the discharge prohibition does not apply. The NSRL provides guidance for determining when this is the case for exposures to chemicals listed as causing cancer.
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