- PEA is a natural compound that supports the body’s response to inflammation, cellular stress, immune activity, and pain signaling.
- It benefits sleep, cognitive function, stress resilience, joint comfort, menstrual comfort, and histamine-related responses.
- PEA Ultra provides 300 mg of Levagen+ PEA using LipiSperse® technology, designed to enhance absorption and bioavailability.
The human body is amazing in all its complexities. Its ability to recover and rejuvenate from birth through all ages demonstrates this beauty. Innumerable factors influence these processes from sleep and glymphatics, digestion and nutrient absorption, to that of brain, immune, and hormonal functions, and much more.
One compound that your body uses daily for recovery and resolving repair challenges is palmitoylethanolamide (PEA). As levels decline, so does your restorative sleep and repair capacity. Discover this remarkable resource and its proven benefits for health.
What Is PEA?
Palmitoylethanolamide (PEA) is a bioactive lipid or fatty acid mediator naturally produced on demand by your body when cells are stressed or injured. Researched since the 1950’s, PEA has been shown to modulate multiple activities involved with neuroprotection, immune function, pain signaling, germ-recognition and more. PEA works by mediating the activity of PPAR-alpha which activates anti-inflammatory actions and provides immune-modulating and stress resolution to cells.
PEA inhibits mast cell release of histamine at the site of tissue irritation and stress. It indirectly and safely mimics your brain’s own natural endocannabinoids via an entourage effect providing essential repair, comfort, and resolution of cell stress. It does not contain THC compounds found in some CBD and hemp products.
PEA levels decline with age and increased demand from ongoing wear-and-tear, tissue injury or illness. Small amounts of PEA are found in foods like palm oil, peanuts, egg yolk, and soy lecithin.
Clinical Trials
In the last few years, several human clinical trials have demonstrated the health benefits and effectiveness of Levagen+ PEA in many different perimeters. The results are impressive!
Sleep Quality
Clinical trials have shown that Levagen+ PEA improves sleep quality. After 8 weeks of taking 350 mg of Levagen+ PEA in healthy adults, results showed faster sleep onset and improved ability to wake up quicker and have better cognitive function upon wakening.
Neuroprotection and BDNF Production
A randomized double-blinded placebo controlled cross-over trial evaluated the effects of 700 mg/day of Levagen+ PEA on neuroprotection and cognitive health enhancement in university students. After 6 weeks of use, test results showed increased levels of serum BDNF. Additional testing showed improved memory and cognitive function with fewer errors.
These results have suggested that Levagen+ PEA should be considered as “an effective nootropic supplement that can be used by populations to support academic study and by the wider general public to improve cognition”.
BDNF is a critical protein found in the brain and other tissues. It is most known for its role in neuroplasticity, nerve growth, maintenance, regeneration, integrity, and neurotransmitter synthesis. BDNF is vital for your brain and body’s ability to adapt to and manage cellular stress.
Stress Resiliency and Heart Rate Variability
A 2025 randomized cross-over trial evaluated the effects of Levagen+ PEA on stress tolerance in female university students. Stress levels were measured with standardized questionnaires as well as heart rate variability that demonstrates heart-autonomic nervous stress resiliency. Results showed improvements in stress tolerance, resiliency, and heart rate variability after 6 weeks of 600 mg of Levagen+ PEA.
Sinus and Histamine
PEA is a known inhibitor of mast cells, blocking the release of histamine. In this double-blind, randomized, placebo-controlled clinical trial, participants received 350 mg of Levagen+ PEA or placebo daily. Those who received PEA for the two-week study had a reduction of histamine, IL-4, IL-8, IL-10, and TNF-a.
Joint Comfort
Knee joint comfort was assessed in adults with age-related joint discomfort. Participants of this double-blind placebo-controlled study received 300 mg, 600 mg or placebo daily for 8 weeks. Both groups who received Levagen+ PEA experienced improvements in comfort, stiffness, pain tolerance, and stress associated concerns regarding their functional joint health.
Menstrual Cycle Comfort
A 2023 Australian study evaluated the effects of Levagen+ PEA with menstrual cycle comfort in women. Participants took either 300 mg of PEA or a placebo rating their comfort over a span of 4 hours. Those who took PEA experienced an overall improvement associated with their menstrual cycle comfort.
Other Studies on Comfort
Other studies of Levagen+ PEA demonstrate improvements in comfort and pain resolution faster and better than placebo or other traditional means of support in various concerns.
Award Winning Absorption of Levagen+ PEA
Levagen+ PEA uses award winning LipiSperse® cold water dispersion technology to increase its absorption and bioavailability in the body. A double-blind availability study showed that 300 mg of Levagen+ PEA with LipiSperse technology increased blood levels by 1.7-fold more than standard forms of PEA. This occurred in healthy adults with rapid absorption peaking at 45 minutes after ingestion.
Key Benefits of PEA
• Faster sleep onset
• Better mental clarity upon awakening
• Improves stress resiliency and heart rate variability
• Enhance production of BDNF
• Effective nootropic support
• Provides comfort for menstrual cycle and other concerns
• Provides support for knee joint comfort
• Inhibits mast cell activation and histamine release
• Supports sinus health
• Supports comfort to stressed tissues
• Levagen+ PEA provides 1.7 times better and more rapid absorption than standard forms
Wellness Resources PEA Ultra provides 300mg of Levagen+ per capsule. It is a clinically studied, award winning form of palmitoylethanolamide which safely increases levels of natural endocannabinoids in the body that regulate sleep, pain, mast cells and histamine, and other functions. Since the 1950’s, researchers have studied the benefits and safety of PEA. Nutritional science now provides it in a highly absorbable nutraceutical grade form to help you get through your day better and age well. Do your own trial and see how it works for you. It’s a game changer for many!
Additional Resources
PEA Calms Digestive Stress and Improves Bowel Motility
The Power of PEA: Feel Better, Think Sharper, Sleep Deeper
PEA Effective for Exercise Recovery and Athletes
PEA for Healthy Mast Cell Activity
PEA Ultra: A Revolutionary Nutrient for Health and Repair
PEA: Natural Support for Nerves and Comfort
Nutrition & Lifestyle Support
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